This national survey finds that among Americans with autism spectrum disorder (ASD), those that also identify as lesbian, gay, bisexual, transgender, or queer (LGBTQ+) not only have worse experiences with healthcare but worse health overall. LGBTQ+ respondents indicated notably worse physical and mental health compared to those that identify as straight and cisgender, and when seeking help for these problems, their needs were less frequently met by providers, with some individuals being refused service entirely. Through the intersection of ASD and sexual or gender identity, this study reveals the health disparities that minority groups in the United States face and discusses what might be done to address them.